Isai is an uncommon variant of Isaiah that peaked in 2007 and remains in steady use.
Isai is predominantly a boy name. In 2025 it ranked #1,139 among boys (186) and #9,099 among girls (11) — overall #2,236 across all names. The charts below show girls and boys separately.
| Year | U.S. births | U.S. + territories | ♀ Rank | ♂ Rank |
|---|---|---|---|---|
| 2025 | 197 | 197 | #9,099 | #1,139 |
| 2024 | 212 | 217 | #12,678 | #1,063 |
| 2023 | 199 | 199 | — | #1,081 |
| 2022 | 160 | 160 | — | #1,232 |
| 2021 | 168 | 168 | — | #1,175 |
| 2020 | 161 | 171 | — | #1,194 |
| 2019 | 207 | 213 | — | #1,011 |
| 2018 | 193 | 204 | — | #1,054 |
| 2017 | 195 | 200 | — | #1,031 |
| 2016 | 185 | 193 | — | #1,066 |
| 2015 | 197 | 206 | — | #1,031 |
| 2014 | 168 | 174 | — | #1,133 |
| 2013 | 191 | 191 | — | #1,026 |
| 2012 | 217 | 227 | #17,884 | #953 |
| 2011 | 237 | 243 | — | #881 |
| 2010 | 241 | 247 | — | #872 |
| 2009 | 270 | 275 | — | #819 |
| 2008 | 310 | 315 | — | #738 |
| 2007 | 333 | 341 | — | #701 |
| 2006 | 305 | 313 | — | #713 |
| 2005 | 274 | 287 | — | #738 |
| 2004 | 275 | 287 | — | #702 |
| 2003 | 243 | 248 | — | #742 |
| 2002 | 250 | 250 | #16,430 | #725 |
| 2001 | 206 | 216 | — | #812 |
| 2000 | 167 | 173 | #13,816 | #944 |
| 1999 | 179 | 187 | — | #847 |
| 1998 | 144 | 154 | — | #963 |
| 1997 | 141 | — | — | #954 |
| 1996 | 149 | — | — | #897 |
| 1995 | 128 | — | — | #982 |
| 1994 | 114 | — | — | #1,044 |
| 1993 | 93 | — | — | #1,160 |
| 1992 | 88 | — | #12,327 | #1,253 |
| 1991 | 90 | — | — | #1,165 |
| 1990 | 92 | — | #13,795 | #1,167 |
| 1989 | 83 | — | — | #1,163 |
| 1988 | 46 | — | — | #1,583 |
| 1987 | 31 | — | — | #1,991 |
| 1986 | 36 | — | — | #1,743 |
| 1985 | 36 | — | — | #1,709 |
| 1984 | 27 | — | — | #2,003 |
| 1983 | 29 | — | — | #1,876 |
| 1982 | 21 | — | — | #2,371 |
| 1981 | 27 | — | — | #2,012 |
| 1980 | 16 | — | — | #2,880 |
| 1979 | 16 | — | — | #2,827 |
| 1978 | 7 | — | — | #4,741 |
| 1977 | 6 | — | — | #5,411 |
| 1976 | 7 | — | — | #4,619 |
| 1975 | 6 | — | — | #5,062 |
| 1973 | 6 | — | — | #4,747 |
| 1966 | 6 | — | — | #3,699 |